This week's lecture was about the design and experimental implementation of DNA origami. DNA origami is the folding of DNA to create non-arbitrary two- and three-dimensional shapes at the nanoscale. The specificity of the interactions between complementary base pairs make DNA a useful construction material, through design of its base sequences. DNA is a well-understood material that is suitable for creating scaffolds that hold other molecules in place or to create structures all on its own.
We learned how to design DNA origami using cadDNAno software. cadDNAno simplifies and enhances the process of designing three-dimensional DNA origami nanostructures. Through its user-friendly 2D and 3D interfaces it accelerates the creation of arbitrary designs. The embedded rules within cadDNAno paired with the finite element analysis performed by CanDo, provide relative certainty of the stability of the structures.